Aspartame was associated with the severity of symptoms for patients with past a history of depression. The results of the 1993 study have not been duplicated and it has been criticized that unrelated symptoms were aggregated artificially.
Adverse Reactions On the Brain
Anecdotal evidence suggests that chronic disease causes relapse after prolonged treatment with antidepressants. The reason for the relapse is that the brain-physiology is said to be changed due to being induced by medications. It could also possible that adverse reactions could be due to the aging process of the brain or worsening of the condition. Most psychiatric medications were planned for short-term use which is considered one year or less.
Consult a Doctor For a Adverse Reactions
It is recommended that physicians respond to relapse by increasing dosage, changing the class of the medication.